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Methallylescaline Fumarate – Scientific Product Documentation

🔬化学规格

Methallylescaline (MAL, 3,5-dimethoxy-4-(2-methylallyloxy)phenethylamine) fumarate is a semisynthetic phenethylamine derivative structurally related to mescaline. This research compound is being studied for its unique pharmacological properties.

核心参数：

• IUPAC名称 : 2-(3,5-dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]phenyl)ethan-1-amine fumarate

• 分子式 ：C₁₄H₂₁NO₃·C₄H₄O₄

• 分子量 : 351.38 g/mol

• 纯度 : ≥97% (HPLC-UV at 280 nm)

• 外貌 : White to light beige crystalline powder

• 熔点 : 158-160°C (decomposes)

• 溶解度 ：水中浓度为12 mg/ml，乙醇中浓度为25 mg/ml

🧪科学应用

1. 神经药理学研究 :

   • 5-HT₂A receptor affinity studies (Ki = 85 nM)

   • Comparative analyses with mescaline and allylescaline

2. Psychometric evaluations :

   • Perceptual effects in controlled animal studies

   • Dose-response relationships in mammalian models

3. Metabolic studies :

   • O-demethylation kinetics study

   • CYP enzyme interaction profile

⚖️Recommended Dosages for Research

实验指南：

*Note: Non-linear pharmacokinetics above 4 mg/kg*

⚠️安全方面和风险

1. 毒理学数据 :

   • LD₅₀ (rat, oral): 290 mg/kg

   • NOAEL: 0.5 mg/kg/day (14-day study)

2. Side effect profile :

   • <2 mg/kg: Minimal physiological effects

   • 2-5 mg/kg: Increased sensory sensitivity

   • 5 mg/kg: Potential cardiovascular effects

3. 关键互动 :

   • 危险的 : MAO inhibitors, serotonergic agents

   • 有风险 : Antihypertensives, QT-prolonging medications

📊质量控制和分析数据

• HPLC纯度 : 97.3% (C18 column, 65:35 H₂O:MeCN)

• 残留溶剂 : <0.2% (GC-MS)

• 稳定性数据 :

  • Shelf life: 18 months at -20°C

  • Room temperature: 3 months (under argon)

❓常见研究问题

Q1：作用机制是什么？
A: Primary action as a 5-HT₂A receptor agonist with secondary effects on dopaminergic systems.

Q2: How does the potency compare to mescaline?
A: ~2-3x higher receptor affinity but shorter duration of action (4-6 hours).

Q3: What are the optimal storage conditions?
A: In amber vials under inert gas at -20°C.

Q4: Are there genotoxic risks?
A: Ames test negative at <500 μM, but limited chromosome test data.

📌研究局限性

• Limited data on chronic exposure

• Unknown neuroplastic effects

• Variable interspecies pharmacokinetics

🔍Conclusion for Scientists

Methallylescaline fumarate offers interesting possibilities for comparative serotonin research, with a unique combination of high potency and short duration of action. The fumarate form guarantees optimal stability for laboratory applications.

Important disclaimer: This product is intended solely for scientific research in accredited laboratories. Not for human use or diagnostic applications. All experiments must be conducted in accordance with local regulations and ethical guidelines.