Металлилескалин фумарат

Methallylescaline Fumarate – Scientific Product Documentation

🔬Химические характеристики

Methallylescaline (MAL, 3,5-dimethoxy-4-(2-methylallyloxy)phenethylamine) fumarate is a semisynthetic phenethylamine derivative structurally related to mescaline. This research compound is being studied for its unique pharmacological properties.

Основные параметры:

• Название ИЮПАК : 2-(3,5-dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]phenyl)ethan-1-amine fumarate

• Молекулярная формула : C₁₄H₂₁NO₃ · C₄H₄O₄

• Молекулярный вес : 351.38 g/mol

• Чистота : ≥97% (HPLC-UV at 280 nm)

• Появление : White to light beige crystalline powder

• Температура плавления : 158-160°C (decomposes)

• Растворимость : 12 мг/мл в воде, 25 мг/мл в этаноле

🧪Научные приложения

1. Нейрофармакологические исследования :

   • 5-HT₂A receptor affinity studies (Ki = 85 nM)

   • Comparative analyses with mescaline and allylescaline

2. Psychometric evaluations :

   • Perceptual effects in controlled animal studies

   • Dose-response relationships in mammalian models

3. Metabolic studies :

   • O-demethylation kinetics study

   • CYP enzyme interaction profile

⚖️Recommended Dosages for Research

Экспериментальные указания:

*Note: Non-linear pharmacokinetics above 4 mg/kg*

⚠️Аспекты безопасности и риски

1. Токсикологические данные :

   • LD₅₀ (rat, oral): 290 mg/kg

   • NOAEL: 0.5 mg/kg/day (14-day study)

2. Side effect profile :

   • <2 mg/kg: Minimal physiological effects

   • 2-5 mg/kg: Increased sensory sensitivity

   • 5 mg/kg: Potential cardiovascular effects

3. Критические взаимодействия :

   • Опасный : MAO inhibitors, serotonergic agents

   • Рискованно : Antihypertensives, QT-prolonging medications

📊Контроль качества и аналитические данные

• Чистота ВЭЖХ : 97.3% (C18 column, 65:35 H₂O:MeCN)

• Residual solvents : <0.2% (GC-MS)

• Данные о стабильности :

  • Shelf life: 18 months at -20°C

  • Room temperature: 3 months (under argon)

❓Часто задаваемые исследовательские вопросы

В1: Каков механизм действия?
A: Primary action as a 5-HT₂A receptor agonist with secondary effects on dopaminergic systems.

Q2: How does the potency compare to mescaline?
A: ~2-3x higher receptor affinity but shorter duration of action (4-6 hours).

Q3: What are the optimal storage conditions?
A: In amber vials under inert gas at -20°C.

Q4: Are there genotoxic risks?
A: Ames test negative at <500 μM, but limited chromosome test data.

📌Ограничения исследования

• Limited data on chronic exposure

• Unknown neuroplastic effects

• Variable interspecies pharmacokinetics

🔍Conclusion for Scientists

Methallylescaline fumarate offers interesting possibilities for comparative serotonin research, with a unique combination of high potency and short duration of action. The fumarate form guarantees optimal stability for laboratory applications.

Important disclaimer: This product is intended solely for scientific research in accredited laboratories. Not for human use or diagnostic applications. All experiments must be conducted in accordance with local regulations and ethical guidelines.