Fumarate de méthallylescaline

Methallylescaline Fumarate – Scientific Product Documentation

🔬Spécifications chimiques

Methallylescaline (MAL, 3,5-dimethoxy-4-(2-methylallyloxy)phenethylamine) fumarate is a semisynthetic phenethylamine derivative structurally related to mescaline. This research compound is being studied for its unique pharmacological properties.

Paramètres de base :

• Nom de l'IUPAC : 2-(3,5-dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]phenyl)ethan-1-amine fumarate

• Formule moléculaire : C₁₄H₂₁NO₃ · C₄H₄O₄

• Poids moléculaire : 351.38 g/mol

• Pureté : ≥97% (HPLC-UV at 280 nm)

• Apparence : White to light beige crystalline powder

• Point de fusion : 158-160°C (decomposes)

• Solubilité : 12 mg/ml dans l'eau, 25 mg/ml dans l'éthanol

🧪Applications scientifiques

1. Recherche neuropharmacologique :

   • 5-HT₂A receptor affinity studies (Ki = 85 nM)

   • Comparative analyses with mescaline and allylescaline

2. Psychometric evaluations :

   • Perceptual effects in controlled animal studies

   • Dose-response relationships in mammalian models

3. Metabolic studies :

   • O-demethylation kinetics study

   • CYP enzyme interaction profile

⚖️Recommended Dosages for Research

Directives expérimentales :

*Note: Non-linear pharmacokinetics above 4 mg/kg*

⚠️Aspects et risques liés à la sécurité

1. Données toxicologiques :

   • LD₅₀ (rat, oral): 290 mg/kg

   • NOAEL: 0.5 mg/kg/day (14-day study)

2. Side effect profile :

   • <2 mg/kg: Minimal physiological effects

   • 2-5 mg/kg: Increased sensory sensitivity

   • 5 mg/kg: Potential cardiovascular effects

3. Interactions critiques :

   • Dangereux : MAO inhibitors, serotonergic agents

   • Risqué : Antihypertensives, QT-prolonging medications

📊Contrôle qualité et données analytiques

• Pureté HPLC : 97.3% (C18 column, 65:35 H₂O:MeCN)

• Solvants résiduels : <0.2% (GC-MS)

• Données de stabilité :

  • Shelf life: 18 months at -20°C

  • Room temperature: 3 months (under argon)

❓Questions de recherche fréquemment posées

Q1 : Quel est le mécanisme d’action ?
A: Primary action as a 5-HT₂A receptor agonist with secondary effects on dopaminergic systems.

Q2: How does the potency compare to mescaline?
A: ~2-3x higher receptor affinity but shorter duration of action (4-6 hours).

Q3: What are the optimal storage conditions?
A: In amber vials under inert gas at -20°C.

Q4: Are there genotoxic risks?
A: Ames test negative at <500 μM, but limited chromosome test data.

📌Limites de la recherche

• Limited data on chronic exposure

• Unknown neuroplastic effects

• Variable interspecies pharmacokinetics

🔍Conclusion for Scientists

Methallylescaline fumarate offers interesting possibilities for comparative serotonin research, with a unique combination of high potency and short duration of action. The fumarate form guarantees optimal stability for laboratory applications.

Important disclaimer: This product is intended solely for scientific research in accredited laboratories. Not for human use or diagnostic applications. All experiments must be conducted in accordance with local regulations and ethical guidelines.