Metallyylieskaliinifumaraatti

Methallylescaline Fumarate – Scientific Product Documentation

🔬Kemialliset tiedot

Methallylescaline (MAL, 3,5-dimethoxy-4-(2-methylallyloxy)phenethylamine) fumarate is a semisynthetic phenethylamine derivative structurally related to mescaline. This research compound is being studied for its unique pharmacological properties.

Ydinparametrit:

• IUPAC-nimi : 2-(3,5-dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]phenyl)ethan-1-amine fumarate

• Molekyylikaava C₁₄H₂₁NO₃ · C₄H₄O₄

• Molekyylipaino : 351.38 g/mol

• Puhtaus : ≥97% (HPLC-UV at 280 nm)

• Ulkonäkö : White to light beige crystalline powder

• Sulamispiste : 158-160°C (decomposes)

• Liukoisuus 12 mg/ml vedessä, 25 mg/ml etanolissa

🧪Tieteelliset sovellukset

1. Neurofarmakologinen tutkimus :

   • 5-HT₂A receptor affinity studies (Ki = 85 nM)

   • Comparative analyses with mescaline and allylescaline

2. Psychometric evaluations :

   • Perceptual effects in controlled animal studies

   • Dose-response relationships in mammalian models

3. Metabolic studies :

   • O-demethylation kinetics study

   • CYP enzyme interaction profile

⚖️Recommended Dosages for Research

Kokeelliset ohjeet:

*Note: Non-linear pharmacokinetics above 4 mg/kg*

⚠️Safety Aspects & Risks

1. Toksikologiset tiedot :

   • LD₅₀ (rat, oral): 290 mg/kg

   • NOAEL: 0.5 mg/kg/day (14-day study)

2. Side effect profile :

   • <2 mg/kg: Minimal physiological effects

   • 2-5 mg/kg: Increased sensory sensitivity

   • 5 mg/kg: Potential cardiovascular effects

3. Kriittiset vuorovaikutukset :

   • Vaarallinen : MAO inhibitors, serotonergic agents

   • Riskialtis : Antihypertensives, QT-prolonging medications

📊Laadunvalvonta ja analyyttiset tiedot

• HPLC-puhtaus : 97.3% (C18 column, 65:35 H₂O:MeCN)

• Jäännösliuottimet : <0.2% (GC-MS)

• Vakaustiedot :

  • Shelf life: 18 months at -20°C

  • Room temperature: 3 months (under argon)

❓Usein kysytyt tutkimuskysymykset

K1: Mikä on vaikutusmekanismi?
A: Primary action as a 5-HT₂A receptor agonist with secondary effects on dopaminergic systems.

Q2: How does the potency compare to mescaline?
A: ~2-3x higher receptor affinity but shorter duration of action (4-6 hours).

Q3: What are the optimal storage conditions?
A: In amber vials under inert gas at -20°C.

Q4: Are there genotoxic risks?
A: Ames test negative at <500 μM, but limited chromosome test data.

📌Tutkimuksen rajoitukset

• Limited data on chronic exposure

• Unknown neuroplastic effects

• Variable interspecies pharmacokinetics

🔍Conclusion for Scientists

Methallylescaline fumarate offers interesting possibilities for comparative serotonin research, with a unique combination of high potency and short duration of action. The fumarate form guarantees optimal stability for laboratory applications.

Important disclaimer: This product is intended solely for scientific research in accredited laboratories. Not for human use or diagnostic applications. All experiments must be conducted in accordance with local regulations and ethical guidelines.