{"id":23504,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/globalsourcechemicals.com\/?post_type=product&p=23504"},"modified":"2025-10-03T18:59:00","modified_gmt":"2025-10-03T18:59:00","slug":"5-meo-dmt-hidroklorid","status":"publish","type":"product","link":"https:\/\/globalsourcechemicals.com\/sl\/trgovina\/kupite-5-meo-dmt\/5-meo-dmt-hidroklorid\/","title":{"rendered":"5-MeO-DMT hidroklorid"},"content":{"rendered":"

5-MeO-DMT Hydrochloride \u2013 Scientific Product Documentation<\/span><\/span><\/strong><\/h3>\n

Splo\u0161ni opis<\/span><\/span><\/strong><\/h4>\n

5-MeO-DMT hydrochloride (5-Methoxy-N,N-dimethyltryptamine HCl) is a water-soluble salt of classical tryptamine, particularly suitable for pharmacological research due to its increased stability and bioavailability compared to the freebase form.<\/span><\/span><\/p>\n

\n

Tehni\u010dne specifikacije<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Parameter<\/span><\/span><\/strong><\/th>\nSpecifikacija<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Kemijska formula<\/span><\/span><\/strong><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O \u00b7 HCl<\/span><\/span><\/td>\n<\/tr>\n
Molekulska te\u017ea<\/span><\/span><\/strong><\/td>\n254,75 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
\u010cistost<\/span><\/span><\/strong><\/td>\n\u226598% (analyzed by HPLC-UV)<\/span><\/span><\/td>\n<\/tr>\n
Videz<\/span><\/span><\/strong><\/td>\nWhite to light yellow crystalline powder<\/span><\/span><\/td>\n<\/tr>\n
Topnost<\/span><\/span><\/strong><\/td>\nHigh in water (>50 mg\/ml), methanol, PBS<\/span><\/span><\/td>\n<\/tr>\n
Tali\u0161\u010de<\/span><\/span><\/strong><\/td>\n243-247\u00b0C (decomposes)<\/span><\/span><\/td>\n<\/tr>\n
Stabilnost<\/span><\/span><\/strong><\/td>\nHygroscopic; store in dry conditions<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Znanstvene aplikacije<\/span><\/span><\/strong><\/h3>\n

1. Neuropharmacology & Behavioral Research<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Serotonin receptor studies:<\/span><\/span><\/strong> \u00a0Potent 5-HT\u2081\u2090\/\u2082\u2090 agonist with rapid cerebral penetration.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Animal experiments (in vivo):<\/span><\/span><\/strong> \u00a0Behavioural paradigms (e.g. head-twitch response in rodents).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Electrophysiology:<\/span><\/span><\/strong> \u00a0Effects on neuronal oscillations (e.g., gamma-band activity).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Biochemical & Molecular Studies<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      Intracellular signaling:<\/span><\/span><\/strong> \u00a0cAMP accumulation and \u03b2-arrestin recruitment assays.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Enzyme kinetics:<\/span><\/span><\/strong> \u00a0MAO-A metabolism (IC\u2085\u2080 ~2-5 \u03bcM).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Clinically Relevant Research<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        Dose-response relationships:<\/span><\/span><\/strong> \u00a0Preclinical safety profiling.<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Comparative pharmacology:<\/span><\/span><\/strong> \u00a0Towards psilocybin, DMT, and other tryptamines.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Eksperimentalne smernice<\/span><\/span><\/strong><\/h3>\n

        Recommended Concentrations<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Uporaba<\/span><\/span><\/strong><\/th>\nObmo\u010dje koncentracije<\/span><\/span><\/strong><\/th>\nTopilo<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
        Cell cultures (in vitro)<\/span><\/span><\/td>\n1 nM \u2013 10 \u03bcM<\/span><\/span><\/td>\nPBS\/DMEM (\u22640,1% DMSO)<\/span><\/span><\/td>\n<\/tr>\n
        Receptor assays<\/span><\/span><\/td>\n0,1\u2013100 \u03bcM<\/span><\/span><\/td>\nTris-HCl pufer (pH 7,4)<\/span><\/span><\/td>\n<\/tr>\n
        Animal studies (ip\/iv)<\/span><\/span><\/td>\n0,1\u20135 mg\/kg<\/span><\/span><\/td>\nSterile saline solution<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        Varnostni ukrepi<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Osebna za\u0161\u010dita:<\/span><\/span><\/strong> \u00a0Lab coat, gloves (nitrile), safety glasses.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Ravnanje:<\/span><\/span><\/strong> \u00a0Hygroscopic \u2013 close promptly after use.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Shranjevanje:<\/span><\/span><\/strong> \u00a0Airtight, under argon, at -20\u00b0C (prevent hydrolysis).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabilnost in shranjevanje<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            Rok uporabnosti:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              -20 \u00b0C:<\/span><\/span><\/strong> \u00a0>2 years (unchanged purity).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4 \u00b0C:<\/span><\/span><\/strong> \u00a06 months (in dry environment).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Relegation:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Hydrolysis on prolonged exposure to moisture (monitor by HPLC).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Analytical Validation<\/span><\/span><\/strong><\/h3>\n

                Each batch comes with:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  HPLC-UV kromatogram<\/span><\/span><\/strong> \u00a0(C18 column, retention time ~6.2 min).<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  MS\/MS fragmentation<\/span><\/span><\/strong> \u00a0(characteristic ions: m\/z 219 \u2192 174, 160).<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  Preostala topila<\/span><\/span><\/strong> \u00a0(meet ICH Q3C guidelines).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Legal Status (Netherlands\/EU)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Narcotics legislation:<\/span><\/span><\/strong> \u00a0Not explicitly mentioned in the Opium Act, but possibly under analogous legislation (Appendix II).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Scientific use:<\/span><\/span><\/strong> \u00a0Permit required for institutions (CCMO approval for animal testing).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Export control:<\/span><\/span><\/strong> \u00a0Subject to EU Regulation 2019\/1998 (psychotropic substances).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    Pogosto zastavljena vpra\u0161anja (FAQ)<\/span><\/span><\/strong><\/h3>\n

                    Q1 <\/span>: What are the advantages of HCl over freebase?<\/span><\/strong><\/span><\/p>\n

                      \n
                    • \n

                      Improved solubility<\/span><\/span><\/strong> \u00a0(ideal for injection studies).<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Longer shelf stability<\/span><\/span><\/strong> \u00a0at room temperature.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      Q2: Is 5-MeO-DMT-HCl detectable in drug tests?<\/span><\/span><\/strong>
                      \n A: Yes, via:<\/span><\/span><\/p>\n

                        \n
                      • \n

                        LC-MS\/MS<\/span><\/span><\/strong> \u00a0(recognized as 5-MeO-DMT + HCl adduct).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Imunoanalize:<\/span><\/span><\/strong> \u00a0Cross-reactivity with DMT (~15-20%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        Q3: Are there risks when combining with MAO inhibitors?<\/span><\/span><\/strong>
                        \n O:\u00a0 <\/span><\/span>Absolutely.<\/span><\/span><\/strong><\/p>\n

                          \n
                        • \n

                          Increased risk of\u00a0 <\/span><\/span>serotonin syndrome<\/span><\/span><\/strong> \u00a0(avoid combination!).<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Use only in MAO-free models.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          V4: Kako odstraniti odpadke?<\/span><\/span><\/strong>
                          \n O:<\/span><\/span><\/p>\n

                            \n
                          1. \n

                            Neutralize with\u00a0 <\/span><\/span>sodium bicarbonate<\/span><\/span><\/strong> \u00a0(pH 7\u20138).<\/span><\/span><\/p>\n<\/li>\n

                          2. \n

                            Adsorb with\u00a0 <\/span><\/span>activated carbon<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n<\/li>\n

                          3. \n

                            Odstranite kot\u00a0 <\/span><\/span>nevarni kemi\u010dni odpadki<\/span><\/span><\/strong> \u00a0(UN 3249, Class 6.1).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                            \n

                            Reference in kontakt<\/span><\/span><\/strong><\/h3>\n

                            Core literature:<\/span><\/span><\/strong><\/p>\n

                              \n
                            1. \n

                              Shen et al. (2010). \u00bbFarmakologija derivatov 5-MeO-DMT\u00ab.\u00a0 <\/span><\/span>J Psychopharmacol<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n

                            2. \n

                              Kaasik in sod. (2021). \u00bbPresnovne poti 5-MeO-DMT\u00ab.\u00a0 <\/span><\/span>Xenobiotics<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                              \n

                              This product is intended only for authorized scientific research. Not for human consumption or diagnostic use. Please observe local regulations.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                              5-MeO-DMT hydrochloride properties<\/span><\/span><\/span><\/h3>\n

                              Synonym:<\/span><\/span><\/strong> 5-methoxy-N,N-dimethyltryptamine hydrochloride <\/span><\/span>
                              \nCAS Number:<\/span><\/span><\/strong> n\/a <\/span><\/span>
                              \nFormula:<\/span><\/span><\/strong> 3-[2-(dimethylamino)ethyl]-5-methoxyindole hydrochloride <\/span><\/span>
                              \nMolar mass:<\/span><\/span><\/strong> 254.8 g\/mol <\/span><\/span>
                              \nPurity:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>\n","protected":false},"featured_media":28465,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":{"0":"post-23504","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-5-meo-dmt-kopen","7":"product_cat-tryptamines","8":"product_tag-nl","10":"first","11":"instock","12":"taxable","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/product\/23504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/comments?post=23504"}],"version-history":[{"count":6,"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/product\/23504\/revisions"}],"predecessor-version":[{"id":28467,"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/product\/23504\/revisions\/28467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/media\/28465"}],"wp:attachment":[{"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/media?parent=23504"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/product_brand?post=23504"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/product_cat?post=23504"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/product_tag?post=23504"}],"curies":[{"name":"delovni list","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}