{"id":23497,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/globalsourcechemicals.com\/?post_type=product&p=23497"},"modified":"2025-10-03T07:29:36","modified_gmt":"2025-10-03T07:29:36","slug":"5-meo-dmt-proste-baze","status":"publish","type":"product","link":"https:\/\/globalsourcechemicals.com\/sl\/trgovina\/kupite-5-meo-dmt\/5-meo-dmt-proste-baze\/","title":{"rendered":"5-MeO-DMT prosta baza"},"content":{"rendered":"

5-MeO-DMT prosta baza \u2013 znanstvena dokumentacija izdelka<\/span><\/span><\/strong><\/h3>\n

Splo\u0161ni opis<\/span><\/span><\/strong><\/h4>\n

5-MeO-DMT (5-metoksi-N,N-dimetiltriptamin) v prosti bazi je naravni triptamin z mo\u010dnim psihoaktivnim profilom, ki ga najdemo v razli\u010dnih rastlinskih in \u017eivalskih izlo\u010dkih. V svoji prosti bazi ponuja vrhunsko hlapnost za nekatere raziskovalne metode, zaradi \u010desar je dragocen za farmakolo\u0161ke in nevroznanstvene \u0161tudije.<\/span><\/span><\/p>\n

\n

Tehni\u010dne specifikacije<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Parameter<\/span><\/span><\/strong><\/th>\nSpecifikacija<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Kemijska formula<\/span><\/span><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O<\/span><\/span><\/td>\n<\/tr>\n
Molekulska te\u017ea<\/span><\/span><\/td>\n218,29 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
\u010cistost<\/span><\/span><\/td>\n\u226598% (analiza HPLC-UV)<\/span><\/span><\/td>\n<\/tr>\n
Obrazec<\/span><\/span><\/td>\nKristalini\u010den\/bel prah<\/span><\/span><\/td>\n<\/tr>\n
Topnost<\/span><\/span><\/td>\nTopen v organskih topilih (etanol, metanol, DMSO), omejeno v vodi<\/span><\/span><\/td>\n<\/tr>\n
Tali\u0161\u010de<\/span><\/span><\/td>\n60\u201365 \u00b0C (prosta baza)<\/span><\/span><\/td>\n<\/tr>\n
Stabilnost<\/span><\/span><\/td>\nOb\u010dutljivo na svetlobo in kisik; shranjujte v inertnem plinu<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Znanstvene aplikacije<\/span><\/span><\/strong><\/h3>\n

1. Nevrofarmakolo\u0161ke raziskave<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Serotoninsko delovanje:<\/span><\/span><\/strong> \u00a0Mo\u010dan agonist 5-HT\u2081\u2090\/\u2082\u2090, pomemben za \u0161tudije modulacije zavesti.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    EEG\/fMRI \u0161tudije:<\/span><\/span><\/strong> \u00a0Preiskava akutnih u\u010dinkov na vzorce mo\u017eganskih valov (npr. gama oscilacije).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Nevroplasti\u010dnost:<\/span><\/span><\/strong> \u00a0Mo\u017eni u\u010dinki, ki krepijo BDNF (v \u017eivalskih modelih).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Presnovne in toksikolo\u0161ke \u0161tudije<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      Presnova, odvisna od MAO:<\/span><\/span><\/strong> \u00a0Preiskava poti razgradnje CYP2D6 in MAO-A.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Od odmerka odvisna toksi\u010dnost:<\/span><\/span><\/strong> \u00a0Dolo\u010danje varnostnih meja v celi\u010dnih kulturah.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Primerjalna farmakologija<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        V primerjavi z DMT:<\/span><\/span><\/strong> \u00a0Ve\u010dja u\u010dinkovitost, vendar kraj\u0161e trajanje delovanja (15\u201330 minut pri vdihavanju).<\/span><\/span><\/p>\n<\/li>\n

      • \n

        V primerjavi s psilocibinom:<\/span><\/span><\/strong> \u00a0Razlike v afiniteti receptorjev in subjektivni u\u010dinki.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Eksperimentalne smernice<\/span><\/span><\/strong><\/h3>\n

        Priporo\u010dene koncentracije (in vitro)<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Uporaba<\/span><\/span><\/th>\nObmo\u010dje koncentracije<\/span><\/span><\/th>\nTopilo<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
        Testi vezave receptorjev<\/span><\/span><\/td>\n1 nM \u2013 10 \u00b5M<\/span><\/span><\/td>\nPBS\/DMSO (\u22640,1%)<\/span><\/span><\/td>\n<\/tr>\n
        Poskusi s celi\u010dnimi kulturami<\/span><\/span><\/td>\n0,1\u2013100 \u00b5M<\/span><\/span><\/td>\nDMEM\/FBS<\/span><\/span><\/td>\n<\/tr>\n
        Plinska kromatografija<\/span><\/span><\/td>\n1 mg\/ml (v metanolu)<\/span><\/span><\/td>\nMetanol (HPLC kakovosti)<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        Varnostni protokoli<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Osebna za\u0161\u010dita:<\/span><\/span><\/strong> \u00a0Laboratorijski pla\u0161\u010d, nitrilne rokavice, za\u0161\u010ditna o\u010dala, maska FFP2 pri delu s prahom.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Prezra\u010devanje:<\/span><\/span><\/strong> \u00a0Pri segrevanju\/izparevanju vedno delajte pod digestorjem.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Shranjevanje:<\/span><\/span><\/strong> \u00a0V jantarnih vialah, pod argonom, pri -20 \u00b0C (dolgoro\u010dno).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabilnost in shranjevanje<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            Rok uporabnosti:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              Sobna temperatura: <24 ur v raztopini.<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4 \u00b0C: Stabilno 3 dni (pod argonom).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              -20 \u00b0C: >6 mesecev (nespremenjena \u010distost).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Produkti razgradnje:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Oksidacija v derivate indola (preverjanje s TLC\/HPLC).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Analiti\u010dno certificiranje<\/span><\/span><\/strong><\/h3>\n

                Vsaka serija vklju\u010duje:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  HPLC-UV kromatogram<\/span><\/span><\/strong> \u00a0(\u03bb=280 nm, kolona C18)<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  Potrditev z GC-MS<\/span><\/span><\/strong> \u00a0(zna\u010dilni fragmenti: m\/z 174, 160)<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  Analiza ostankov topila<\/span><\/span><\/strong> \u00a0(\u2264500 ppm)<\/span><\/span><\/p>\n<\/li>\n

                4. \n

                  Vsebnost vode<\/span><\/span><\/strong> \u00a0(Karl Fischer, <1%)<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Pravni status (Nizozemska)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Zakon o opiju:<\/span><\/span><\/strong> \u00a0Ni izrecno urejeno, vendar morda v skladu z analogno zakonodajo.<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Zakonodaja:<\/span><\/span><\/strong> \u00a0Za znanstvene ustanove je potrebno dovoljenje (Dodatek 2 k Zakonu o opiju).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Izvozne omejitve:<\/span><\/span><\/strong> \u00a0uvrstitev na seznam CITES (zaradi naravnih virov, kot so\u00a0 <\/span><\/span>Incilius alvarius<\/span><\/span><\/em> ).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    Pogosto zastavljena vpra\u0161anja (FAQ)<\/span><\/span><\/strong><\/h3>\n

                    V1: Kak\u0161na je razlika med prosto bazo in soljo fumarne kisline?<\/span><\/span><\/strong>
                    \n A: Prosta baza je bolj hlapna (primerna za poskuse izhlapevanja), medtem ko je sol fumarne kisline v raztopinah stabilnej\u0161a.<\/span><\/span><\/p>\n

                    V2: Kako se 5-MeO-DFT zazna v toksikolo\u0161kih preiskavah?<\/span><\/span><\/strong>
                    \n A: Prepoznavno po:<\/span><\/span><\/p>\n

                      \n
                    • \n

                      LC-MS\/MS (predhodni ion m\/z 219 \u2192 produktni ion m\/z 174)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Imunolo\u0161ki testi: Navzkri\u017ena reaktivnost z nekaterimi DMT testi (\u226430%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      V3: Ali obstajajo kak\u0161ne znane farmakokineti\u010dne interakcije?<\/span><\/span><\/strong>
                      \n O:\u00a0 <\/span><\/span>Nevarne kombinacije:<\/span><\/span><\/strong><\/p>\n

                        \n
                      • \n

                        Zaviralci MAO (tveganje za serotoninski sindrom).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        SSRI (zmanj\u0161ana u\u010dinkovitost zaradi konkurence).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        V4: Kako odstraniti odpadke?<\/span><\/span><\/strong>
                        \n A: Deaktiviraj z:<\/span><\/span><\/p>\n

                          \n
                        1. \n

                          Za nevtralizacijo uporabite razred\u010deno klorovodikovo kislino (0,1 M).<\/span><\/span><\/p>\n<\/li>\n

                        2. \n

                          Absorpcija z aktivnim ogljem.<\/span><\/span><\/p>\n<\/li>\n

                        3. \n

                          Odstranite kot\u00a0 <\/span><\/span>nevarni kemi\u010dni odpadki<\/span><\/span><\/em> \u00a0(\u0160tevilka ZN: 3249).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                          \n

                          Reference in kontakt<\/span><\/span><\/strong><\/h3>\n

                          Klju\u010dne publikacije:<\/span><\/span><\/strong><\/p>\n

                            \n
                          • \n

                            Sz\u00e1ra, S. (2007). "DMT in 5-MeO-DMT: zgodnje \u0161tudije na ljudeh".<\/span><\/span><\/p>\n<\/li>\n

                          • \n

                            Uthaug et al. (2021). Psihofarmakologija 5-MeO-DMT.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                            \n

                            Ta izdelek je namenjen izklju\u010dno legitimnim znanstvenim raziskavam. Ni za uporabo v humani ali veterinarski medicini. Uporabniki morajo upo\u0161tevati vse lokalne predpise.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                            5-MeO-DMT freebase properties<\/span><\/span><\/span><\/span><\/h3>\n

                            Synonym:<\/span><\/span><\/span><\/span><\/strong> 5-methoxy-N,N-dimethyltryptamine <\/span><\/span><\/span><\/span>
                            \nCAS Number:<\/span><\/span><\/span><\/span><\/strong> 1019-45-0 <\/span><\/span><\/span><\/span>
                            \nFormula:<\/span><\/span><\/span><\/span><\/strong> 3-[2-(dimethylamino)ethyl]-5-methoxyindole <\/span><\/span><\/span><\/span>
                            \nMolar Mass:<\/span><\/span><\/span><\/span><\/strong> 218.3 g\/mol <\/span><\/span><\/span><\/span>
                            \nPurity:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>\n","protected":false},"featured_media":27829,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":{"0":"post-23497","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-5-meo-dmt-kopen","7":"product_cat-tryptamines","8":"product_tag-nl","10":"first","11":"instock","12":"taxable","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/product\/23497","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/comments?post=23497"}],"version-history":[{"count":4,"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/product\/23497\/revisions"}],"predecessor-version":[{"id":28072,"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/product\/23497\/revisions\/28072"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/media\/27829"}],"wp:attachment":[{"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/media?parent=23497"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/product_brand?post=23497"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/product_cat?post=23497"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/sl\/wp-json\/wp\/v2\/product_tag?post=23497"}],"curies":[{"name":"delovni list","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}