{"id":23497,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/globalsourcechemicals.com\/?post_type=product&p=23497"},"modified":"2025-10-03T07:29:36","modified_gmt":"2025-10-03T07:29:36","slug":"5-meo-dmt-freebase","status":"publish","type":"product","link":"https:\/\/globalsourcechemicals.com\/nb\/butikk\/kjop-5-meo-dmt\/5-meo-dmt-freebase\/","title":{"rendered":"5-MeO-DMT fribase"},"content":{"rendered":"

5-MeO-DMT Freebase \u2013 Vitenskapelig produktdokumentasjon<\/span><\/span><\/strong><\/h3>\n

Generell beskrivelse<\/span><\/span><\/strong><\/h4>\n

5-MeO-DMT (5-metoksy-N,N-dimetyltryptamin) fri base er et naturlig forekommende tryptamin med en potent psykoaktiv profil, som finnes i forskjellige plante- og dyresekresjoner. I sin frie baseform tilbyr den overlegen flyktighet for visse forskningsmetoder, noe som gj\u00f8r den verdifull for farmakologiske og nevrovitenskapelige studier.<\/span><\/span><\/p>\n

\n

Tekniske spesifikasjoner<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Parameter<\/span><\/span><\/strong><\/th>\nSpesifikasjon<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Kjemisk formel<\/span><\/span><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O<\/span><\/span><\/td>\n<\/tr>\n
Molekylvekt<\/span><\/span><\/td>\n218,29 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
Renhet<\/span><\/span><\/td>\n\u226598% (HPLC-UV-analysert)<\/span><\/span><\/td>\n<\/tr>\n
Skjema<\/span><\/span><\/td>\nKrystallinsk\/hvitt pulver<\/span><\/span><\/td>\n<\/tr>\n
L\u00f8selighet<\/span><\/span><\/td>\nL\u00f8selig i organiske l\u00f8semidler (etanol, metanol, DMSO), begrenset i vann<\/span><\/span><\/td>\n<\/tr>\n
Smeltepunkt<\/span><\/span><\/td>\n60\u201365 \u00b0C (fri base)<\/span><\/span><\/td>\n<\/tr>\n
Stabilitet<\/span><\/span><\/td>\nLys- og oksygenf\u00f8lsom; oppbevares under inert gass<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Vitenskapelige anvendelser<\/span><\/span><\/strong><\/h3>\n

1. Nevrofarmakologisk forskning<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Serotonerg virkning:<\/span><\/span><\/strong> \u00a0Potent 5-HT\u2081\u2090\/\u2082\u2090-agonist, relevant for studier av bevissthetsmodulering.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    EEG\/fMRI-studier:<\/span><\/span><\/strong> \u00a0Unders\u00f8kelse av akutte effekter p\u00e5 hjerneb\u00f8lgem\u00f8nstre (f.eks. gammaoscillasjoner).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Nevroplastisitet:<\/span><\/span><\/strong> \u00a0Mulige BDNF-forsterkende effekter (i dyremodeller).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Metabolske og toksikologiske studier<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      MAO-avhengig metabolisme:<\/span><\/span><\/strong> \u00a0Unders\u00f8kelse av nedbrytningsveier for CYP2D6 og MAO-A.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Doseavhengig toksisitet:<\/span><\/span><\/strong> \u00a0Bestemmelse av sikkerhetsmarginer i cellekulturer.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Komparativ farmakologi<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        Sammenlignet med DMT:<\/span><\/span><\/strong> \u00a0H\u00f8yere potens, men kortere virkningsvarighet (15\u201330 minutter ved inhalasjon).<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Sammenlignet med psilocybin:<\/span><\/span><\/strong> \u00a0Forskjeller i reseptoraffinitet og subjektive effekter.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Eksperimentelle retningslinjer<\/span><\/span><\/strong><\/h3>\n

        Anbefalte konsentrasjoner (in vitro)<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        S\u00f8knad<\/span><\/span><\/th>\nKonsentrasjonsomr\u00e5de<\/span><\/span><\/th>\nL\u00f8semiddel<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
        Reseptorbindingsanalyser<\/span><\/span><\/td>\n1 nM \u2013 10 \u00b5M<\/span><\/span><\/td>\nPBS\/DMSO (\u22640,1%)<\/span><\/span><\/td>\n<\/tr>\n
        Cellekultureksperimenter<\/span><\/span><\/td>\n0,1\u2013100 \u00b5M<\/span><\/span><\/td>\nDMEM\/FBS<\/span><\/span><\/td>\n<\/tr>\n
        Gasskromatografi<\/span><\/span><\/td>\n1 mg\/ml (i metanol)<\/span><\/span><\/td>\nMetanol (HPLC-kvalitet)<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        Sikkerhetsprotokoller<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Personlig beskyttelse:<\/span><\/span><\/strong> \u00a0Laboratoriefrakk, nitrilhansker, vernebriller og FFP2-maske ved h\u00e5ndtering av pulver.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Ventilasjon:<\/span><\/span><\/strong> \u00a0Arbeid alltid under et avtrekksskap ved oppvarming\/fordamping.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Lagring:<\/span><\/span><\/strong> \u00a0I ravfargede hetteglass, under argon, ved -20 \u00b0C (langvarig).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabilitet og lagring<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            Holdbarhet:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              Romtemperatur: <24 timer i l\u00f8sning.<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4 \u00b0C: Stabil i 3 dager (under argon).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              -20 \u00b0C: >6 m\u00e5neder (uendret renhet).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Nedbrytningsprodukter:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Oksidasjon til indolderivater (sjekk med TLC\/HPLC).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Analytisk sertifisering<\/span><\/span><\/strong><\/h3>\n

                Hvert parti inneholder:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  HPLC-UV-kromatogram<\/span><\/span><\/strong> \u00a0(\u03bb=280 nm, C18-kolonne)<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  GC-MS-bekreftelse<\/span><\/span><\/strong> \u00a0(karakteristiske fragmenter: m\/z 174, 160)<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  Analyse av gjenv\u00e6rende l\u00f8semiddel<\/span><\/span><\/strong> \u00a0(\u2264500 ppm)<\/span><\/span><\/p>\n<\/li>\n

                4. \n

                  Vanninnhold<\/span><\/span><\/strong> \u00a0(Karl Fischer, <1%)<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Juridisk status (Nederland)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Opiumloven:<\/span><\/span><\/strong> \u00a0Ikke eksplisitt regulert, men muligens under analog lovgivning.<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Lovgivning:<\/span><\/span><\/strong> \u00a0Det kreves lisens for vitenskapelige institusjoner (vedlegg 2, opiumloven).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Eksportrestriksjoner:<\/span><\/span><\/strong> \u00a0CITES-oppf\u00f8ring (p\u00e5 grunn av naturlige kilder som\u00a0 <\/span><\/span>Incilius alvarius<\/span><\/span><\/em> ).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    Ofte stilte sp\u00f8rsm\u00e5l (FAQ)<\/span><\/span><\/strong><\/h3>\n

                    Q1: Hva er forskjellen mellom fribase og fumarsyresalt?<\/span><\/span><\/strong>
                    \n A: Fribase er mer flyktig (egnet for fordampningseksperimenter), mens fumarsyresalt er mer stabilt i l\u00f8sninger.<\/span><\/span><\/p>\n

                    Sp\u00f8rsm\u00e5l 2: Hvordan p\u00e5vises 5-MeO-DFT i toksikologiske screeninger?<\/span><\/span><\/strong>
                    \n A: Identifiserbar ved:<\/span><\/span><\/p>\n

                      \n
                    • \n

                      LC-MS\/MS (forl\u00f8perion m\/z 219 \u2192 produktion m\/z 174)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Immunoanalyser: Kryssreaktivitet med noen DMT-tester (\u226430%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      Q3: Finnes det noen kjente farmakokinetiske interaksjoner?<\/span><\/span><\/strong>
                      \n EN:\u00a0 <\/span><\/span>Farlige kombinasjoner:<\/span><\/span><\/strong><\/p>\n

                        \n
                      • \n

                        MAO-hemmere (risiko for serotonergt syndrom).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        SSRI-er (redusert effekt p\u00e5 grunn av konkurranse).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        Q4: Hvordan skal man kvitte seg med avfall?<\/span><\/span><\/strong>
                        \n A: Deaktiver med:<\/span><\/span><\/p>\n

                          \n
                        1. \n

                          Fortynn saltsyre (0,1 M) for n\u00f8ytralisering.<\/span><\/span><\/p>\n<\/li>\n

                        2. \n

                          Absorpsjon med aktivt kull.<\/span><\/span><\/p>\n<\/li>\n

                        3. \n

                          Kast som\u00a0 <\/span><\/span>farlig kjemisk avfall<\/span><\/span><\/em> \u00a0(FN-nummer: 3249).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                          \n

                          Referanser og kontakt<\/span><\/span><\/strong><\/h3>\n

                          Viktige publikasjoner:<\/span><\/span><\/strong><\/p>\n

                            \n
                          • \n

                            Szara, S. (2007). "DMT og 5-MeO-DMT: Tidlige menneskelige studier".<\/span><\/span><\/p>\n<\/li>\n

                          • \n

                            Uthaug et al. (2021). "Psykofarmakologi av 5-MeO-DMT".<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                            \n

                            Dette produktet er utelukkende beregnet for legitim vitenskapelig forskning. Ikke til bruk p\u00e5 mennesker eller dyr. Brukere m\u00e5 overholde alle lokale forskrifter.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                            5-MeO-DMT freebase properties<\/span><\/span><\/span><\/span><\/h3>\n

                            Synonym:<\/span><\/span><\/span><\/span><\/strong> 5-methoxy-N,N-dimethyltryptamine <\/span><\/span><\/span><\/span>
                            \nCAS Number:<\/span><\/span><\/span><\/span><\/strong> 1019-45-0 <\/span><\/span><\/span><\/span>
                            \nFormula:<\/span><\/span><\/span><\/span><\/strong> 3-[2-(dimethylamino)ethyl]-5-methoxyindole <\/span><\/span><\/span><\/span>
                            \nMolar Mass:<\/span><\/span><\/span><\/span><\/strong> 218.3 g\/mol <\/span><\/span><\/span><\/span>
                            \nPurity:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>\n","protected":false},"featured_media":27829,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":{"0":"post-23497","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-5-meo-dmt-kopen","7":"product_cat-tryptamines","8":"product_tag-nl","10":"first","11":"instock","12":"taxable","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/globalsourcechemicals.com\/nb\/wp-json\/wp\/v2\/product\/23497","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/globalsourcechemicals.com\/nb\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/globalsourcechemicals.com\/nb\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/nb\/wp-json\/wp\/v2\/comments?post=23497"}],"version-history":[{"count":4,"href":"https:\/\/globalsourcechemicals.com\/nb\/wp-json\/wp\/v2\/product\/23497\/revisions"}],"predecessor-version":[{"id":28072,"href":"https:\/\/globalsourcechemicals.com\/nb\/wp-json\/wp\/v2\/product\/23497\/revisions\/28072"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/nb\/wp-json\/wp\/v2\/media\/27829"}],"wp:attachment":[{"href":"https:\/\/globalsourcechemicals.com\/nb\/wp-json\/wp\/v2\/media?parent=23497"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/nb\/wp-json\/wp\/v2\/product_brand?post=23497"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/nb\/wp-json\/wp\/v2\/product_cat?post=23497"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/nb\/wp-json\/wp\/v2\/product_tag?post=23497"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}