{"id":23497,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/globalsourcechemicals.com\/?post_type=product&p=23497"},"modified":"2025-10-03T07:29:36","modified_gmt":"2025-10-03T07:29:36","slug":"5-meo-dmt-freebase","status":"publish","type":"product","link":"https:\/\/globalsourcechemicals.com\/fr_be\/boutique\/achetez-5-meo-dmt\/5-meo-dmt-freebase\/","title":{"rendered":"5-MeO-DMT base libre"},"content":{"rendered":"

5-MeO-DMT base libre \u2013 Documentation scientifique du produit<\/span><\/span><\/strong><\/h3>\n

Description g\u00e9n\u00e9rale<\/span><\/span><\/strong><\/h4>\n

La 5-MeO-DMT (5-m\u00e9thoxy-N,N-dim\u00e9thyltryptamine) base libre est une tryptamine naturelle au puissant profil psychoactif, pr\u00e9sente dans diverses s\u00e9cr\u00e9tions v\u00e9g\u00e9tales et animales. Sous sa forme base libre, elle offre une volatilit\u00e9 sup\u00e9rieure pour certaines m\u00e9thodes de recherche, ce qui la rend pr\u00e9cieuse pour les \u00e9tudes pharmacologiques et neuroscientifiques.<\/span><\/span><\/p>\n

\n

Sp\u00e9cifications techniques<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Param\u00e8tre<\/span><\/span><\/strong><\/th>\nSp\u00e9cification<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Formule chimique<\/span><\/span><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O<\/span><\/span><\/td>\n<\/tr>\n
Poids mol\u00e9culaire<\/span><\/span><\/td>\n218,29 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
Puret\u00e9<\/span><\/span><\/td>\n\u226598% (analys\u00e9 par HPLC-UV)<\/span><\/span><\/td>\n<\/tr>\n
Formulaire<\/span><\/span><\/td>\nPoudre cristalline\/blanche<\/span><\/span><\/td>\n<\/tr>\n
Solubilit\u00e9<\/span><\/span><\/td>\nSoluble dans les solvants organiques (\u00e9thanol, m\u00e9thanol, DMSO), limit\u00e9 dans l'eau<\/span><\/span><\/td>\n<\/tr>\n
Point de fusion<\/span><\/span><\/td>\n60-65\u00b0C (base libre)<\/span><\/span><\/td>\n<\/tr>\n
Stabilit\u00e9<\/span><\/span><\/td>\nSensible \u00e0 la lumi\u00e8re et \u00e0 l'oxyg\u00e8ne ; conserver sous gaz inerte<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Applications scientifiques<\/span><\/span><\/strong><\/h3>\n

1. Recherche neuropharmacologique<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Action s\u00e9rotoninergique :<\/span><\/span><\/strong> \u00a0Agoniste puissant 5-HT\u2081\u2090\/\u2082\u2090, pertinent pour les \u00e9tudes de modulation de la conscience.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    \u00c9tudes EEG\/IRMf :<\/span><\/span><\/strong> \u00a0\u00c9tude des effets aigus sur les sch\u00e9mas d\u2019ondes c\u00e9r\u00e9brales (par exemple, les oscillations gamma).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Neuroplasticit\u00e9 :<\/span><\/span><\/strong> \u00a0Effets possibles d\u2019am\u00e9lioration du BDNF (dans les mod\u00e8les animaux).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. \u00c9tudes m\u00e9taboliques et toxicologiques<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      M\u00e9tabolisme d\u00e9pendant de la MAO :<\/span><\/span><\/strong> \u00a0\u00c9tude des voies de d\u00e9gradation du CYP2D6 et de la MAO-A.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Toxicit\u00e9 dose-d\u00e9pendante :<\/span><\/span><\/strong> \u00a0D\u00e9termination des marges de s\u00e9curit\u00e9 dans les cultures cellulaires.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Pharmacologie compar\u00e9e<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        Compar\u00e9 au DMT :<\/span><\/span><\/strong> \u00a0Puissance plus \u00e9lev\u00e9e mais dur\u00e9e d'action plus courte (15 \u00e0 30 minutes en cas d'inhalation).<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Par rapport \u00e0 la psilocybine :<\/span><\/span><\/strong> \u00a0Diff\u00e9rences dans l\u2019affinit\u00e9 des r\u00e9cepteurs et effets subjectifs.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Directives exp\u00e9rimentales<\/span><\/span><\/strong><\/h3>\n

        Concentrations recommand\u00e9es (in vitro)<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Application<\/span><\/span><\/th>\nPlage de concentration<\/span><\/span><\/th>\nSolvant<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
        Dosages de liaison aux r\u00e9cepteurs<\/span><\/span><\/td>\n1 nM \u2013 10 \u00b5M<\/span><\/span><\/td>\nPBS\/DMSO (\u22640,1%)<\/span><\/span><\/td>\n<\/tr>\n
        Exp\u00e9riences de culture cellulaire<\/span><\/span><\/td>\n0,1 \u2013 100 \u00b5M<\/span><\/span><\/td>\nDMEM\/FBS<\/span><\/span><\/td>\n<\/tr>\n
        Chromatographie en phase gazeuse<\/span><\/span><\/td>\n1 mg\/ml (dans le m\u00e9thanol)<\/span><\/span><\/td>\nM\u00e9thanol (qualit\u00e9 HPLC)<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        Protocoles de s\u00e9curit\u00e9<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Protection personnelle :<\/span><\/span><\/strong> \u00a0Blouse de laboratoire, gants en nitrile, lunettes de s\u00e9curit\u00e9, masque FFP2 lors de la manipulation de poudre.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Ventilation:<\/span><\/span><\/strong> \u00a0Travaillez toujours sous une hotte aspirante lors du chauffage\/\u00e9vaporation.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Stockage:<\/span><\/span><\/strong> \u00a0En flacons ambr\u00e9s, sous argon, \u00e0 -20\u00b0C (longue dur\u00e9e).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabilit\u00e9 et stockage<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            Dur\u00e9e de conservation :<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              Temp\u00e9rature ambiante : < 24 heures en solution.<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4\u00b0C : Stable 3 jours (sous argon).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              -20\u00b0C : >6 mois (puret\u00e9 inchang\u00e9e).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Produits de d\u00e9gradation :<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Oxydation en d\u00e9riv\u00e9s indoliques (v\u00e9rification par CCM\/HPLC).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Certification analytique<\/span><\/span><\/strong><\/h3>\n

                Chaque lot comprend :<\/span><\/span><\/p>\n

                  \n
                1. \n

                  Chromatogramme HPLC-UV<\/span><\/span><\/strong> \u00a0(\u03bb=280 nm, colonne C18)<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  Confirmation GC-MS<\/span><\/span><\/strong> \u00a0(fragments caract\u00e9ristiques : m\/z 174, 160)<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  Analyse des solvants r\u00e9siduels<\/span><\/span><\/strong> \u00a0(\u2264 500 ppm)<\/span><\/span><\/p>\n<\/li>\n

                4. \n

                  Teneur en eau<\/span><\/span><\/strong> \u00a0(Karl Fischer, <1%)<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Statut juridique (Pays-Bas)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Loi sur l'opium :<\/span><\/span><\/strong> \u00a0Non explicitement r\u00e9glement\u00e9, mais peut-\u00eatre soumis \u00e0 une l\u00e9gislation analogue.<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    L\u00e9gislation:<\/span><\/span><\/strong> \u00a0Une licence est requise pour les institutions scientifiques (annexe 2, loi sur l\u2019opium).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Restrictions \u00e0 l\u2019exportation :<\/span><\/span><\/strong> \u00a0Inscription \u00e0 la CITES (en raison de sources naturelles telles que\u00a0 <\/span><\/span>Incilius alvarius<\/span><\/span><\/em> ).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    Foire aux questions (FAQ)<\/span><\/span><\/strong><\/h3>\n

                    Q1 : Quelle est la diff\u00e9rence entre la base libre et le sel d\u2019acide fumarique ?<\/span><\/span><\/strong>
                    \n R : La base libre est plus volatile (adapt\u00e9e aux exp\u00e9riences d'\u00e9vaporation), tandis que le sel d'acide fumarique est plus stable dans les solutions.<\/span><\/span><\/p>\n

                    Q2 : Comment le 5-MeO-DFT est-il d\u00e9tect\u00e9 dans les tests toxicologiques ?<\/span><\/span><\/strong>
                    \n A : Identifiable par :<\/span><\/span><\/p>\n

                      \n
                    • \n

                      LC-MS\/MS (ion pr\u00e9curseur m\/z 219 \u2192 ion produit m\/z 174)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Immunoessais : R\u00e9activit\u00e9 crois\u00e9e avec certains tests DMT (\u226430%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      Q3 : Existe-t-il des interactions pharmacocin\u00e9tiques connues ?<\/span><\/span><\/strong>
                      \n UN:\u00a0 <\/span><\/span>Combinaisons dangereuses :<\/span><\/span><\/strong><\/p>\n

                        \n
                      • \n

                        Inhibiteurs de la MAO (risque de syndrome s\u00e9rotoninergique).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        ISRS (efficacit\u00e9 r\u00e9duite en raison de la comp\u00e9tition).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        Q4 : Comment \u00e9liminer les d\u00e9chets ?<\/span><\/span><\/strong>
                        \n A : D\u00e9sactiver avec :<\/span><\/span><\/p>\n

                          \n
                        1. \n

                          Diluer l\u2019acide chlorhydrique (0,1 M) pour la neutralisation.<\/span><\/span><\/p>\n<\/li>\n

                        2. \n

                          Absorption au charbon actif.<\/span><\/span><\/p>\n<\/li>\n

                        3. \n

                          \u00c9liminer comme\u00a0 <\/span><\/span>d\u00e9chets chimiques dangereux<\/span><\/span><\/em> \u00a0(Num\u00e9ro ONU : 3249).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                          \n

                          R\u00e9f\u00e9rences et contact<\/span><\/span><\/strong><\/h3>\n

                          Principales publications :<\/span><\/span><\/strong><\/p>\n

                            \n
                          • \n

                            Szara, S. (2007). "DMT et 5-MeO-DMT\u00a0: premi\u00e8res \u00e9tudes humaines".<\/span><\/span><\/p>\n<\/li>\n

                          • \n

                            Uthaug et coll. (2021). "Psychopharmacologie du 5-MeO-DMT".<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                            \n

                            Ce produit est destin\u00e9 uniquement \u00e0 la recherche scientifique l\u00e9gitime. Il ne convient pas \u00e0 un usage humain ou v\u00e9t\u00e9rinaire. Les utilisateurs doivent se conformer \u00e0 la r\u00e9glementation locale.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                            5-MeO-DMT freebase properties<\/span><\/span><\/span><\/span><\/h3>\n

                            Synonym:<\/span><\/span><\/span><\/span><\/strong> 5-methoxy-N,N-dimethyltryptamine <\/span><\/span><\/span><\/span>
                            \nCAS Number:<\/span><\/span><\/span><\/span><\/strong> 1019-45-0 <\/span><\/span><\/span><\/span>
                            \nFormula:<\/span><\/span><\/span><\/span><\/strong> 3-[2-(dimethylamino)ethyl]-5-methoxyindole <\/span><\/span><\/span><\/span>
                            \nMolar Mass:<\/span><\/span><\/span><\/span><\/strong> 218.3 g\/mol <\/span><\/span><\/span><\/span>
                            \nPurity:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>\n","protected":false},"featured_media":27829,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":{"0":"post-23497","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-5-meo-dmt-kopen","7":"product_cat-tryptamines","8":"product_tag-nl","10":"first","11":"instock","12":"taxable","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/globalsourcechemicals.com\/fr_be\/wp-json\/wp\/v2\/product\/23497","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/globalsourcechemicals.com\/fr_be\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/globalsourcechemicals.com\/fr_be\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/fr_be\/wp-json\/wp\/v2\/comments?post=23497"}],"version-history":[{"count":4,"href":"https:\/\/globalsourcechemicals.com\/fr_be\/wp-json\/wp\/v2\/product\/23497\/revisions"}],"predecessor-version":[{"id":28072,"href":"https:\/\/globalsourcechemicals.com\/fr_be\/wp-json\/wp\/v2\/product\/23497\/revisions\/28072"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/fr_be\/wp-json\/wp\/v2\/media\/27829"}],"wp:attachment":[{"href":"https:\/\/globalsourcechemicals.com\/fr_be\/wp-json\/wp\/v2\/media?parent=23497"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/fr_be\/wp-json\/wp\/v2\/product_brand?post=23497"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/fr_be\/wp-json\/wp\/v2\/product_cat?post=23497"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/fr_be\/wp-json\/wp\/v2\/product_tag?post=23497"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}