{"id":23358,"date":"2025-04-13T17:39:37","date_gmt":"2025-04-13T17:39:37","guid":{"rendered":"https:\/\/globalsourcechemicals.com\/?post_type=product&p=23358"},"modified":"2025-10-03T07:45:12","modified_gmt":"2025-10-03T07:45:12","slug":"pastilles-dmxe-40-mg-de-desoxymethoxetamine","status":"publish","type":"product","link":"https:\/\/globalsourcechemicals.com\/fr\/boutique\/arylcyclohexylamine\/pastilles-dmxe-40-mg-de-desoxymethoxetamine\/","title":{"rendered":"Pastilles DMXE 40 mg (d\u00e9soxym\u00e9thox\u00e9tamine)"},"content":{"rendered":"

Granul\u00e9s DMXE (d\u00e9soxym\u00e9thox\u00e9tamine) 40 mg \u2013 Documentation scientifique du produit<\/span><\/span><\/strong><\/h3>\n

\ud83d\udd2cSp\u00e9cifications chimiques<\/span><\/span><\/strong><\/h4>\n

Le DMXE (2\u2032-Oxo-PCE-d10) est un produit chimique de recherche appartenant \u00e0 la classe des arylcyclohexylamines, structurellement apparent\u00e9 au MXE (m\u00e9thox\u00e9tamine) et \u00e0 la k\u00e9tamine. Ces granul\u00e9s sont formul\u00e9s pour la recherche scientifique de pr\u00e9cision.<\/span><\/span><\/p>\n

Param\u00e8tres de base :<\/span><\/span><\/em><\/p>\n

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  • \n

    Nom de l'IUPAC<\/span><\/span><\/strong> : 2-(3,4-dim\u00e9thylph\u00e9nyl)-2-(\u00e9thylamino)cyclohexanone<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Formule mol\u00e9culaire<\/span><\/span><\/strong> : C\u2081\u2086H\u2082\u2083NO<\/span><\/span><\/p>\n<\/li>\n

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    Poids mol\u00e9culaire<\/span><\/span><\/strong> : 245,36 g\/mol<\/span><\/span><\/p>\n<\/li>\n

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    Puret\u00e9<\/span><\/span><\/strong> : \u226598% (analyse GC-MS)<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Forme<\/span><\/span><\/strong> : Granul\u00e9s ronds de 4 mm de diam\u00e8tre<\/span><\/span><\/p>\n<\/li>\n

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    Couleur<\/span><\/span><\/strong> : Beige clair \u00e0 blanc<\/span><\/span><\/p>\n<\/li>\n

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    Solubilit\u00e9<\/span><\/span><\/strong> : 15 mg\/ml dans l'eau (\u00e0 25\u00b0C)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddeaApplications scientifiques<\/span><\/span><\/strong><\/h4>\n
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    1. \n

      Recherche neuropharmacologique<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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        \u00c9tudes d'antagonisme des r\u00e9cepteurs NMDA<\/span><\/span><\/p>\n<\/li>\n

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        Dosages d'interaction avec le r\u00e9cepteur Sigma-1<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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        Neurosciences comportementales<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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          Effets sur le comportement d'apprentissage chez les animaux de laboratoire<\/span><\/span><\/p>\n<\/li>\n

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          Effets dissociatifs dose-d\u00e9pendants<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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          Psychopharmacologie<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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            \u00c9tudes comparatives avec des dissociatifs apparent\u00e9s<\/span><\/span><\/p>\n<\/li>\n

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            Recherche sur les effets neuroplastiques<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0fProtocoles de recherche recommand\u00e9s<\/span><\/span><\/strong><\/h4>\n

            Directives exp\u00e9rimentales :<\/span><\/span><\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Mod\u00e8le<\/span><\/span><\/th>\nDosage<\/span><\/span><\/th>\nFr\u00e9quence<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/span><\/span><\/td>\n10-50 \u03bcM<\/span><\/span><\/td>\nExposition unique<\/span><\/span><\/td>\n<\/tr>\n
            Petits rongeurs<\/span><\/span><\/td>\n5-20 mg\/kg<\/span><\/span><\/td>\n1x\/jour (max 3 jours)<\/span><\/span><\/td>\n<\/tr>\n
            Primates<\/span><\/span><\/td>\n1 \u00e0 5 mg\/kg<\/span><\/span><\/td>\nDose unique<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Remarque\u00a0: pharmacocin\u00e9tique non lin\u00e9aire au-dessus de 25\u00a0mg\/kg*<\/span><\/span><\/p>\n

            \u26a0\ufe0fProfil de s\u00e9curit\u00e9 et gestion des risques<\/span><\/span><\/strong><\/h4>\n
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            1. \n

              Donn\u00e9es toxicologiques<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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              • \n

                DL\u2085\u2080 (rat, voie orale) : 320 mg\/kg<\/span><\/span><\/p>\n<\/li>\n

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                NOAEL\u00a0: 5 mg\/kg\/jour (\u00e9tude de 7 jours)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

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                Spectre des effets secondaires<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                • \n

                  < 10 mg : effets comportementaux subtils<\/span><\/span><\/p>\n<\/li>\n

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                  10-30 mg : Incoordination motrice<\/span><\/span><\/p>\n<\/li>\n

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                  \n

                  30 mg : d\u00e9pression respiratoire potentielle<\/span><\/span><\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

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                  Interactions critiques<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                  • \n

                    Dangereux<\/span><\/span><\/strong> : Opio\u00efdes, GABA-ergiques<\/span><\/span><\/p>\n<\/li>\n

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                    Risqu\u00e9<\/span><\/span><\/strong> : Stimulants, inhibiteurs de la MAO<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udccaContr\u00f4le qualit\u00e9 et donn\u00e9es analytiques<\/span><\/span><\/strong><\/h4>\n
                      \n
                    • \n

                      Puret\u00e9 HPLC<\/span><\/span><\/strong> : 98,5% (colonne C18, 70:30 H\u2082O:MeCN)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Uniformit\u00e9<\/span><\/span><\/strong> : \u00b15% \u00e9cart de poids (n=20 granul\u00e9s)<\/span><\/span><\/p>\n<\/li>\n

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                      Temps de d\u00e9sint\u00e9gration<\/span><\/span><\/strong> : <15 minutes (dans le suc gastrique simultan\u00e9)<\/span><\/span><\/p>\n<\/li>\n

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                      Donn\u00e9es de stabilit\u00e9<\/span><\/span><\/strong> :<\/span><\/span><\/p>\n

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                        Dur\u00e9e de conservation : 24 mois \u00e0 15-25\u00b0C<\/span><\/span><\/p>\n<\/li>\n

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                        Sensibilit\u00e9 \u00e0 l'humidit\u00e9 : < 0,5% gain de poids (93% RH)<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753Questions de recherche fr\u00e9quemment pos\u00e9es<\/span><\/span><\/strong><\/h4>\n

                        Q1 : Quel est le m\u00e9canisme d\u2019action ?<\/span><\/span><\/strong>
                        \n A : Antagonisme primaire du r\u00e9cepteur NMDA avec inhibition secondaire de la recapture de la dopamine.<\/span><\/span><\/p>\n

                        Q2 : Comment la puissance se compare-t-elle \u00e0 celle de la k\u00e9tamine ?<\/span><\/span><\/strong>
                        \n A : ~0,6 fois la puissance de la k\u00e9tamine mais une demi-vie plus longue (4 \u00e0 6 heures).<\/span><\/span><\/p>\n

                        Q3 : Existe-t-il des risques neurotoxiques ?<\/span><\/span><\/strong>
                        \n A : Les l\u00e9sions d\u2019Olney n\u2019ont pas \u00e9t\u00e9 observ\u00e9es \u00e0 < 50 mg\/kg (\u00e9tude sur le rat).<\/span><\/span><\/p>\n

                        Q4 : Quelle est la m\u00e9thode de stockage optimale ?<\/span><\/span><\/strong>
                        \n A : Dans l'emballage d'origine \u00e0 15-25\u00b0C, \u00e0 l'abri de l'humidit\u00e9.<\/span><\/span><\/p>\n

                        \ud83d\udcccLimites de la recherche<\/span><\/span><\/strong><\/h4>\n
                          \n
                        • \n

                          Donn\u00e9es limit\u00e9es sur l'administration chronique<\/span><\/span><\/p>\n<\/li>\n

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                          Effets inconnus sur la transmission du glutamate<\/span><\/span><\/p>\n<\/li>\n

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                          Biotransformation variable entre les esp\u00e8ces<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0dConclusion pour les chercheurs<\/span><\/span><\/strong><\/h4>\n

                          Les granul\u00e9s DMXE 40 mg offrent une formulation standardis\u00e9e pour des \u00e9tudes dissociatives pr\u00e9cises, avec une administration posologique uniforme et une bonne stabilit\u00e9. Leur forme facilite l'administration quantitative lors des \u00e9tudes animales.<\/span><\/span><\/p>\n

                          Avis de non-responsabilit\u00e9 scientifique\u00a0: Ce produit est destin\u00e9 uniquement \u00e0 la recherche in vitro et aux \u00e9tudes pr\u00e9cliniques autoris\u00e9es. Non destin\u00e9 \u00e0 l'usage humain. Toutes les exp\u00e9riences doivent \u00eatre conformes aux directives \u00e9thiques et \u00e0 la r\u00e9glementation locale en vigueur. Veuillez prendre connaissance du statut particulier des substances psychoactives utilis\u00e9es \u00e0 des fins de recherche dans votre juridiction.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Fonctionnalit\u00e9s DMXE<\/span><\/span><\/span><\/span><\/h3>\n

                          Synonyme:<\/span><\/span><\/span><\/span><\/strong> Chlorhydrate de d\u00e9soxym\u00e9thox\u00e9tamine <\/span><\/span><\/span><\/span>
                          \nNum\u00e9ro CAS :<\/span><\/span><\/span><\/span><\/strong> 681440-83-5 <\/span><\/span><\/span><\/span>
                          \nFormule:<\/span><\/span><\/span><\/span><\/strong> 5-d\u00e9hydro-1,3-quinodim\u00e9thane <\/span><\/span><\/span><\/span>
                          \nMasse molaire :<\/span><\/span><\/span><\/span><\/strong> 103,14 g\/mol <\/span><\/span><\/span><\/span>
                          \nPuret\u00e9:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>","protected":false},"featured_media":27873,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[71,406,429,324],"product_tag":[326],"class_list":{"0":"post-23358","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-arylcyclohexylamine","7":"product_cat-dmxe","8":"product_cat-dmxe-pellets","9":"product_cat-pellets-for-pellet","10":"product_tag-nl","12":"first","13":"instock","14":"taxable","15":"shipping-taxable","16":"purchasable","17":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/globalsourcechemicals.com\/fr\/wp-json\/wp\/v2\/product\/23358","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/globalsourcechemicals.com\/fr\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/globalsourcechemicals.com\/fr\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/fr\/wp-json\/wp\/v2\/comments?post=23358"}],"version-history":[{"count":5,"href":"https:\/\/globalsourcechemicals.com\/fr\/wp-json\/wp\/v2\/product\/23358\/revisions"}],"predecessor-version":[{"id":28083,"href":"https:\/\/globalsourcechemicals.com\/fr\/wp-json\/wp\/v2\/product\/23358\/revisions\/28083"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/fr\/wp-json\/wp\/v2\/media\/27873"}],"wp:attachment":[{"href":"https:\/\/globalsourcechemicals.com\/fr\/wp-json\/wp\/v2\/media?parent=23358"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/fr\/wp-json\/wp\/v2\/product_brand?post=23358"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/fr\/wp-json\/wp\/v2\/product_cat?post=23358"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/fr\/wp-json\/wp\/v2\/product_tag?post=23358"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}