{"id":23497,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/globalsourcechemicals.com\/?post_type=product&p=23497"},"modified":"2025-10-03T07:29:36","modified_gmt":"2025-10-03T07:29:36","slug":"5-miljonit-dmt-vaba-baasi","status":"publish","type":"product","link":"https:\/\/globalsourcechemicals.com\/et\/pood\/osta-5-miljonit-dmt-d\/5-miljonit-dmt-vaba-baasi\/","title":{"rendered":"5-MeO-DMT vaba alus"},"content":{"rendered":"

5-MeO-DMT vaba alus \u2013 teaduslik tootedokumentatsioon<\/span><\/span><\/strong><\/h3>\n

\u00dcldine kirjeldus<\/span><\/span><\/strong><\/h4>\n

5-MeO-DMT (5-metoks\u00fc-N,N-dimet\u00fc\u00fcltr\u00fcptamiin) vaba alusena on looduslikult esinev tr\u00fcptamiin, millel on tugev ps\u00fchhoaktiivne profiil ja mida leidub erinevates taimedes ja loomade eritistes. Vaba alusena pakub see teatud uurimismeetodite jaoks suurep\u00e4rast lenduvust, muutes selle v\u00e4\u00e4rtuslikuks farmakoloogilistes ja neuroteaduslikes uuringutes.<\/span><\/span><\/p>\n

\n

Tehnilised andmed<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Parameeter<\/span><\/span><\/strong><\/th>\nSpetsifikatsioon<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Keemiline valem<\/span><\/span><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O<\/span><\/span><\/td>\n<\/tr>\n
Molekulaarmass<\/span><\/span><\/td>\n218,29 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
Puhtus<\/span><\/span><\/td>\n\u226598% (HPLC-UV anal\u00fc\u00fcsitud)<\/span><\/span><\/td>\n<\/tr>\n
Vorm<\/span><\/span><\/td>\nKristalliline\/valge pulber<\/span><\/span><\/td>\n<\/tr>\n
Lahustuvus<\/span><\/span><\/td>\nLahustub orgaanilistes lahustites (etanool, metanool, DMSO), piiratud koguses vees<\/span><\/span><\/td>\n<\/tr>\n
Sulamistemperatuur<\/span><\/span><\/td>\n60\u201365 \u00b0C (vaba alus)<\/span><\/span><\/td>\n<\/tr>\n
Stabiilsus<\/span><\/span><\/td>\nValgus- ja hapnikutundlik; hoida inertgaasi keskkonnas<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Teaduslikud rakendused<\/span><\/span><\/strong><\/h3>\n

1. Neurofarmakoloogilised uuringud<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Serotonergiline toime:<\/span><\/span><\/strong> \u00a0Tugev 5-HT\u2081\u2090\/\u2082\u2090 agonist, oluline teadvuse modulatsiooni uuringutes.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    EEG\/fMRI uuringud:<\/span><\/span><\/strong> \u00a0Ajulainete mustritele avalduvate \u00e4gedate m\u00f5jude uurimine (nt gammav\u00f5nkumised).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Neuroplastilisus:<\/span><\/span><\/strong> \u00a0V\u00f5imalikud BDNF-i v\u00f5imendavad efektid (loommudelites).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Ainevahetus- ja toksikoloogilised uuringud<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      MAO-s\u00f5ltuv metabolism:<\/span><\/span><\/strong> \u00a0CYP2D6 ja MAO-A lagunemisradade uurimine.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Annusest s\u00f5ltuv toksilisus:<\/span><\/span><\/strong> \u00a0Ohutuspiiride m\u00e4\u00e4ramine rakukultuurides.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. V\u00f5rdlev farmakoloogia<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        V\u00f5rreldes DMT-ga:<\/span><\/span><\/strong> \u00a0Suurem tugevus, kuid l\u00fchem toimeaeg (sissehingamisel 15\u201330 minutit).<\/span><\/span><\/p>\n<\/li>\n

      • \n

        V\u00f5rreldes psilots\u00fcbiiniga:<\/span><\/span><\/strong> \u00a0Retseptori afiinsuse ja subjektiivsete m\u00f5jude erinevused.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Katsejuhised<\/span><\/span><\/strong><\/h3>\n

        Soovitatavad kontsentratsioonid (in vitro)<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        Taotlus<\/span><\/span><\/th>\nKontsentratsioonivahemik<\/span><\/span><\/th>\nLahusti<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
        Retseptori sidumise testid<\/span><\/span><\/td>\n1 nM \u2013 10 \u00b5M<\/span><\/span><\/td>\nPBS\/DMSO (\u22640,1%)<\/span><\/span><\/td>\n<\/tr>\n
        Rakukultuuri katsed<\/span><\/span><\/td>\n0,1\u2013100 \u00b5M<\/span><\/span><\/td>\nDMEM\/FBS<\/span><\/span><\/td>\n<\/tr>\n
        Gaasikromatograafia<\/span><\/span><\/td>\n1 mg\/ml (metanoolis)<\/span><\/span><\/td>\nMetanool (HPLC-kvaliteediga)<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        Ohutusprotokollid<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Isikukaitse:<\/span><\/span><\/strong> \u00a0Pulbri k\u00e4sitsemisel tuleb kanda laborikitlit, nitriilkindaid, kaitseprille ja FFP2-maski.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Ventilatsioon:<\/span><\/span><\/strong> \u00a0Kuumutamise\/aurustamise ajal t\u00f6\u00f6tage alati t\u00f5mbekapi all.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          S\u00e4ilitamine:<\/span><\/span><\/strong> \u00a0Merevaikklaasis viaalides, argooni keskkonnas, temperatuuril -20 \u00b0C (pikaajaline).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabiilsus ja ladustamine<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            S\u00e4ilivusaeg:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              Toatemperatuur: <24 tundi lahuses.<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4\u00b0C: Stabiilne 3 p\u00e4eva (argooni atmosf\u00e4\u00e4ris).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              -20\u00b0C: >6 kuud (puhtus ei muutu).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Lagunemisproduktid:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Oks\u00fcdeerimine indooli derivaatideks (kontrollige TLC\/HPLC abil).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Anal\u00fc\u00fctiline sertifitseerimine<\/span><\/span><\/strong><\/h3>\n

                Iga partii sisaldab:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  HPLC-UV kromatogramm<\/span><\/span><\/strong> \u00a0(\u03bb = 280 nm, C18 kolonn)<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  GC-MS kinnitus<\/span><\/span><\/strong> \u00a0(iseloomulikud fragmendid: m\/z 174, 160)<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  J\u00e4\u00e4nud lahusti anal\u00fc\u00fcs<\/span><\/span><\/strong> \u00a0(\u2264500 ppm)<\/span><\/span><\/p>\n<\/li>\n

                4. \n

                  Veesisaldus<\/span><\/span><\/strong> \u00a0(Karl Fischer, <1%)<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  \u00d5iguslik staatus (Holland)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Oopiumiseadus:<\/span><\/span><\/strong> \u00a0Pole otseselt reguleeritud, aga v\u00f5imalik, et analoogsete \u00f5igusaktide alusel.<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Seadusandlus:<\/span><\/span><\/strong> \u00a0Teadusasutustel on vaja litsentsi (lisa 2, oopiumiseadus).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Ekspordipiirangud:<\/span><\/span><\/strong> \u00a0CITESi loetelu (looduslike allikate, n\u00e4iteks\u00a0 <\/span><\/span>Incilius alvarius<\/span><\/span><\/em> ).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    Korduma kippuvad k\u00fcsimused (KKK)<\/span><\/span><\/strong><\/h3>\n

                    K1: Mis vahe on vabal alusel ja fumaarhappe soolal?<\/span><\/span><\/strong>
                    \n A: Vaba alus on lenduvam (sobib aurustamiskatseteks), samas kui fumaarhappe sool on lahustes stabiilsem.<\/span><\/span><\/p>\n

                    K2: Kuidas tuvastatakse 5-MeO-DFT-d toksikoloogilistes s\u00f5eluuringutes?<\/span><\/span><\/strong>
                    \n A: Tuvastatav j\u00e4rgmise j\u00e4rgi:<\/span><\/span><\/p>\n

                      \n
                    • \n

                      LC-MS\/MS (eelk\u00e4siooni m\/z 219 \u2192 produktiooni m\/z 174)<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Immunoanal\u00fc\u00fcsid: ristreaktsioon m\u00f5nede DMT-testidega (\u226430%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      K3: Kas on teadaolevaid farmakokineetilisi koostoimeid?<\/span><\/span><\/strong>
                      \n V:\u00a0 <\/span><\/span>Ohtlikud kombinatsioonid:<\/span><\/span><\/strong><\/p>\n

                        \n
                      • \n

                        MAO inhibiitorid (serotoniini s\u00fcndroomi oht).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        SSRI-d (v\u00e4henenud efektiivsus konkurentsi t\u00f5ttu).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        K4: Kuidas j\u00e4\u00e4tmeid utiliseerida?<\/span><\/span><\/strong>
                        \n A: Inaktiveeri koos:<\/span><\/span><\/p>\n

                          \n
                        1. \n

                          Neutraliseerimiseks lahjendatud vesinikkloriidhape (0,1 M).<\/span><\/span><\/p>\n<\/li>\n

                        2. \n

                          Imendumine aktiivs\u00f6ega.<\/span><\/span><\/p>\n<\/li>\n

                        3. \n

                          H\u00e4vitage j\u00e4rgmiselt\u00a0 <\/span><\/span>ohtlikud keemilised j\u00e4\u00e4tmed<\/span><\/span><\/em> \u00a0(\u00dcRO number: 3249).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                          \n

                          Viited ja kontakt<\/span><\/span><\/strong><\/h3>\n

                          Peamised publikatsioonid:<\/span><\/span><\/strong><\/p>\n

                            \n
                          • \n

                            Sz\u00e1ra, S. (2007). "DMT ja 5-MeO-DMT: varajased inimuuringud".<\/span><\/span><\/p>\n<\/li>\n

                          • \n

                            Uthaug et al. (2021). "5-MeO-DMT ps\u00fchhofarmakoloogia".<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                            \n

                            See toode on ette n\u00e4htud \u00fcksnes \u00f5igusp\u00e4raseks teaduslikuks uurimist\u00f6\u00f6ks. Mitte inimestele ega loomadele. Kasutajad peavad j\u00e4rgima k\u00f5iki kohalikke eeskirju.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                            5-MeO-DMT freebase properties<\/span><\/span><\/span><\/span><\/h3>\n

                            Synonym:<\/span><\/span><\/span><\/span><\/strong> 5-methoxy-N,N-dimethyltryptamine <\/span><\/span><\/span><\/span>
                            \nCAS Number:<\/span><\/span><\/span><\/span><\/strong> 1019-45-0 <\/span><\/span><\/span><\/span>
                            \nFormula:<\/span><\/span><\/span><\/span><\/strong> 3-[2-(dimethylamino)ethyl]-5-methoxyindole <\/span><\/span><\/span><\/span>
                            \nMolar Mass:<\/span><\/span><\/span><\/span><\/strong> 218.3 g\/mol <\/span><\/span><\/span><\/span>
                            \nPurity:<\/span><\/span><\/span><\/span><\/strong> >97%<\/span><\/span><\/span><\/span><\/p>\n","protected":false},"featured_media":27829,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":{"0":"post-23497","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-5-meo-dmt-kopen","7":"product_cat-tryptamines","8":"product_tag-nl","10":"first","11":"instock","12":"taxable","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/globalsourcechemicals.com\/et\/wp-json\/wp\/v2\/product\/23497","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/globalsourcechemicals.com\/et\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/globalsourcechemicals.com\/et\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/et\/wp-json\/wp\/v2\/comments?post=23497"}],"version-history":[{"count":4,"href":"https:\/\/globalsourcechemicals.com\/et\/wp-json\/wp\/v2\/product\/23497\/revisions"}],"predecessor-version":[{"id":28072,"href":"https:\/\/globalsourcechemicals.com\/et\/wp-json\/wp\/v2\/product\/23497\/revisions\/28072"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/et\/wp-json\/wp\/v2\/media\/27829"}],"wp:attachment":[{"href":"https:\/\/globalsourcechemicals.com\/et\/wp-json\/wp\/v2\/media?parent=23497"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/et\/wp-json\/wp\/v2\/product_brand?post=23497"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/et\/wp-json\/wp\/v2\/product_cat?post=23497"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/globalsourcechemicals.com\/et\/wp-json\/wp\/v2\/product_tag?post=23497"}],"curies":[{"name":"t\u00f6\u00f6leht","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}